The purpose of this integrative review is to examine the literature regarding nurse-led educational interventions, transitional care (TC) strategies for heart failure (HF) patients, nurse navigation, HF self-care, and the clinical nurse leader (CNL) role to support integrating a CNL into the care delivery model serving as a nurse navigator (NN) for adult HF patients being discharged home from the hospital. The basis for this review is to identify an innovative way to improve patient reported and clinical outcomes for the HF population which increases each year. The economic and symptom burden associated with this disease is high further enhanced by poor transitions in care leading to avoidable hospital readmissions. Whittemore and Knafl’s (2005) methodology and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines served as the framework for this review. A total of 32 articles were obtained after an extensive literature search each addressing one of the five components to be examined for synthesis. The information gathered collectively supports a CNL integrated care delivery model best conveyed in a structure, process, outcome model.