Ets in the Kidney—Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension

Joseph C. Gigliotti; Thu H. Lee

Ets in the Kidney—Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension

Liberty University

Research output: Contribution to journal › Article

Abstract

Originally identified as a homolog of a viral oncogene (v-ets), the ETS family of transcription factors consists of over 25 proteins involved in regulating several biologic processes at the transcriptional level. The ETS DNA binding domain consists of a winged helix conformation and binds the DNA sequences 5′-GGA(A/T)-3′ with varying affinity depending on ETS phosphorylation status, epigenetic modifications, and various protein-protein interactions.

Original language	Undefined/Unknown
Journal	Faculty Publications and Presentations
State	Published - Nov 1 2017

Access to Document

http://digitalcommons.liberty.edu/lucom_fac_pubs/25

Cite this

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title = "Ets in the Kidney—Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension",

abstract = "Originally identified as a homolog of a viral oncogene (v-ets), the ETS family of transcription factors consists of over 25 proteins involved in regulating several biologic processes at the transcriptional level. The ETS DNA binding domain consists of a winged helix conformation and binds the DNA sequences 5′-GGA(A/T)-3′ with varying affinity depending on ETS phosphorylation status, epigenetic modifications, and various protein-protein interactions.",

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AU - Gigliotti, Joseph C.

AU - Lee, Thu H.

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N2 - Originally identified as a homolog of a viral oncogene (v-ets), the ETS family of transcription factors consists of over 25 proteins involved in regulating several biologic processes at the transcriptional level. The ETS DNA binding domain consists of a winged helix conformation and binds the DNA sequences 5′-GGA(A/T)-3′ with varying affinity depending on ETS phosphorylation status, epigenetic modifications, and various protein-protein interactions.

AB - Originally identified as a homolog of a viral oncogene (v-ets), the ETS family of transcription factors consists of over 25 proteins involved in regulating several biologic processes at the transcriptional level. The ETS DNA binding domain consists of a winged helix conformation and binds the DNA sequences 5′-GGA(A/T)-3′ with varying affinity depending on ETS phosphorylation status, epigenetic modifications, and various protein-protein interactions.

M3 - Article

JO - Faculty Publications and Presentations

JF - Faculty Publications and Presentations

ER -