Medical emergencies occur every day in school settings across America. School nurses have a vital role in providing care for individuals experiencing a medical emergency and leading a multidisciplinary team during a medical emergency event. Since incidences of medical emergencies are commonplace, it is standard to have protocols and guidelines for these events. To address this concern, an evidence-based practice project was implemented in a rural school district in North Georgia. The pilot project was developed and implemented to assess the effectiveness of implementing a “Medical Emergency Chain of Command Protocol.” The protocol was developed to improve the effectiveness and efficiency of multidisciplinary communication during a medical emergency in the school setting. The Health Service Department team members were given a preimplementation and postimplementation assessment to evaluate the protocol’s effectiveness and a preeducational and posteducational survey to assess the effectiveness of an educational in-service to improve the team member’s knowledge about using a chain of command. The pilot study was conducted over a 60-day implementation period. After thorough data collection and analysis were completed, the results showed that implementation of a medical emergency chain of command protocol in the school setting positively impacts multidisciplinary communication during and after a medical emergency event in the school setting.