Nanomaterials as Active Components in Chemical Warfare Agent Barrier Creams

E H Braue; J D Boecker; B F Doxzon; R L Hall; R T Simons; T L Nohe; R L Stoemer; Stephen Hobson

Nanomaterials as Active Components in Chemical Warfare Agent Barrier Creams

E H Braue, J D Boecker, B F Doxzon, R L Hall, R T Simons, T L Nohe, R L Stoemer, Stephen Hobson

School of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A material that acts as a physical barrier and an active destructive matrix against chemical warfare agents is vital to military operations in chemically contaminated environments. Our research into active topical skin protectants (aTSPs) identified nanomaterials as a promising class of reactive moieties. We determined the efficacy of aTSPs against sulfur mustard (HD) and soman (GD). Using a penetration cell, we determined the cumulative amount of agent that penetrates the aTSP. Proof of neutralization of these materials was obtained using two assays: headspace GC/MS and one- and twodimensional NMR. Both organic and inorganic nanomaterials showed efficacy against GD and/or HD. Relative to the inactive base cream, incorporation of nanomaterials into the aTSPs resulted in a 99.6% reduction of both GD and HD vapor after 20 hours. None of these nanomaterials, however, passed the initial in vivo testing with HD vapor

Original language	American English
Journal	Defense Applications of Nanomaterials
Volume	891
State	Published - Jan 2002

Disciplines

Chemistry

Cite this

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title = "Nanomaterials as Active Components in Chemical Warfare Agent Barrier Creams",

abstract = " A material that acts as a physical barrier and an active destructive matrix against chemical warfare agents is vital to military operations in chemically contaminated environments. Our research into active topical skin protectants (aTSPs) identified nanomaterials as a promising class of reactive moieties. We determined the efficacy of aTSPs against sulfur mustard (HD) and soman (GD). Using a penetration cell, we determined the cumulative amount of agent that penetrates the aTSP. Proof of neutralization of these materials was obtained using two assays: headspace GC/MS and one- and twodimensional NMR. Both organic and inorganic nanomaterials showed efficacy against GD and/or HD. Relative to the inactive base cream, incorporation of nanomaterials into the aTSPs resulted in a 99.6% reduction of both GD and HD vapor after 20 hours. None of these nanomaterials, however, passed the initial in vivo testing with HD vapor",

author = "Braue, {E H} and Boecker, {J D} and Doxzon, {B F} and Hall, {R L} and Simons, {R T} and Nohe, {T L} and Stoemer, {R L} and Stephen Hobson",

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journal = "Defense Applications of Nanomaterials",

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TY - JOUR

T1 - Nanomaterials as Active Components in Chemical Warfare Agent Barrier Creams

AU - Braue, E H

AU - Boecker, J D

AU - Doxzon, B F

AU - Hall, R L

AU - Simons, R T

AU - Nohe, T L

AU - Stoemer, R L

AU - Hobson, Stephen

N1 - A material that acts as a physical barrier and an active destructive matrix against chemical warfare agents is vital to military operations in chemically contaminated environments. Our research into active topical skin protectants (aTSPs) identified nanomaterials as a promising class of reactive moieties. We determined the efficacy of aTSPs against sulfur mustard (HD) and soman (GD).

PY - 2002/1

Y1 - 2002/1

N2 - A material that acts as a physical barrier and an active destructive matrix against chemical warfare agents is vital to military operations in chemically contaminated environments. Our research into active topical skin protectants (aTSPs) identified nanomaterials as a promising class of reactive moieties. We determined the efficacy of aTSPs against sulfur mustard (HD) and soman (GD). Using a penetration cell, we determined the cumulative amount of agent that penetrates the aTSP. Proof of neutralization of these materials was obtained using two assays: headspace GC/MS and one- and twodimensional NMR. Both organic and inorganic nanomaterials showed efficacy against GD and/or HD. Relative to the inactive base cream, incorporation of nanomaterials into the aTSPs resulted in a 99.6% reduction of both GD and HD vapor after 20 hours. None of these nanomaterials, however, passed the initial in vivo testing with HD vapor

AB - A material that acts as a physical barrier and an active destructive matrix against chemical warfare agents is vital to military operations in chemically contaminated environments. Our research into active topical skin protectants (aTSPs) identified nanomaterials as a promising class of reactive moieties. We determined the efficacy of aTSPs against sulfur mustard (HD) and soman (GD). Using a penetration cell, we determined the cumulative amount of agent that penetrates the aTSP. Proof of neutralization of these materials was obtained using two assays: headspace GC/MS and one- and twodimensional NMR. Both organic and inorganic nanomaterials showed efficacy against GD and/or HD. Relative to the inactive base cream, incorporation of nanomaterials into the aTSPs resulted in a 99.6% reduction of both GD and HD vapor after 20 hours. None of these nanomaterials, however, passed the initial in vivo testing with HD vapor

UR - https://pubs.acs.org/doi/abs/10.1021/bk-2005-0891.ch011

M3 - Article

VL - 891

JO - Defense Applications of Nanomaterials

JF - Defense Applications of Nanomaterials

ER -

Nanomaterials as Active Components in Chemical Warfare Agent Barrier Creams

Abstract

Disciplines

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