Synthesis and unusual stability of pyridine and in/i‐methyl pyridinium 1,3‐dioxolanes

<div class="line" id="line-5"> Differentially substituted bridged pyridinium oximes are necessary in research on antidotes for organophosphate poisoning. A solid&hyphen;phase synthesis would improve the yield and ease of purification of these compounds. To predict the lability of the linker in the final step of our proposed synthesis, we synthesized a series of pyridine and <i> N </i> &hyphen;methyl pyridinium acetals. These compounds proved to be resistant to acid catalyzed hydrolysis. This stability may be useful for synthetic manipulation of pyridine aldehydes.</div>