Targeted Heat Shock Protein 72 (HSP72) for Pulmonary Cytoprotection

Missag H Parseghian; Stephen Hobson; Richard A Richieri

doi:10.1111/nyas.13059

Targeted Heat Shock Protein 72 (HSP72) for Pulmonary Cytoprotection

Missag H Parseghian, Stephen Hobson, Richard A Richieri

School of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Heat shock protein 72 (HSP72) is perhaps the most important member of the HSP70 family of proteins, given that it is induced in a wide variety of tissues and cells to combat stress, particularly oxidative stress. Here we review independent observations of the critical role this protein plays as a pulmonary cytoprotectant and discuss the merits of developing HSP72 as a therapeutic for rapid delivery to cells and tissues after a traumatic event. We also discuss the fusion of HSP72 to a cell-penetrating single-chain Fv (scFv) antibody fragment derived from mAb 3E10, referred to as Fv-HSP70. This fusion construct has been validated in vivo in a cerebral infarction model and is currently in testing as a clinical therapeutic to treat ischemic events and as a fieldable medical countermeasure to treat inhalation of toxicants caused by terrorist actions or industrial accidents.

Original language	American English
Journal	Annals of the New York Academy of Sciences
Volume	1374
DOIs	https://doi.org/10.1111/nyas.13059
State	Published - Jun 2016

Keywords

HSP70
HSP72
oxidative stress
apoptosis inhibitor
medical countermeasure
reperfusion therapy

Disciplines

Medicine and Health Sciences

Access to Document

10.1111/nyas.13059License: Unspecified

Cite this

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title = "Targeted Heat Shock Protein 72 (HSP72) for Pulmonary Cytoprotection",

abstract = " Heat shock protein 72 (HSP72) is perhaps the most important member of the HSP70 family of proteins, given that it is induced in a wide variety of tissues and cells to combat stress, particularly oxidative stress. Here we review independent observations of the critical role this protein plays as a pulmonary cytoprotectant and discuss the merits of developing HSP72 as a therapeutic for rapid delivery to cells and tissues after a traumatic event. We also discuss the fusion of HSP72 to a cell-penetrating single-chain Fv (scFv) antibody fragment derived from mAb 3E10, referred to as Fv-HSP70. This fusion construct has been validated in vivo in a cerebral infarction model and is currently in testing as a clinical therapeutic to treat ischemic events and as a fieldable medical countermeasure to treat inhalation of toxicants caused by terrorist actions or industrial accidents.",

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T1 - Targeted Heat Shock Protein 72 (HSP72) for Pulmonary Cytoprotection

AU - Parseghian, Missag H

AU - Hobson, Stephen

AU - Richieri, Richard A

N1 - Heat shock protein 72 (HSP72) is perhaps the most important member of the HSP70 family of proteins, given that it is induced in a wide variety of tissues and cells to combat stress, particularly oxidative stress. Here we review independent observations ...

PY - 2016/6

Y1 - 2016/6

N2 - Heat shock protein 72 (HSP72) is perhaps the most important member of the HSP70 family of proteins, given that it is induced in a wide variety of tissues and cells to combat stress, particularly oxidative stress. Here we review independent observations of the critical role this protein plays as a pulmonary cytoprotectant and discuss the merits of developing HSP72 as a therapeutic for rapid delivery to cells and tissues after a traumatic event. We also discuss the fusion of HSP72 to a cell-penetrating single-chain Fv (scFv) antibody fragment derived from mAb 3E10, referred to as Fv-HSP70. This fusion construct has been validated in vivo in a cerebral infarction model and is currently in testing as a clinical therapeutic to treat ischemic events and as a fieldable medical countermeasure to treat inhalation of toxicants caused by terrorist actions or industrial accidents.

AB - Heat shock protein 72 (HSP72) is perhaps the most important member of the HSP70 family of proteins, given that it is induced in a wide variety of tissues and cells to combat stress, particularly oxidative stress. Here we review independent observations of the critical role this protein plays as a pulmonary cytoprotectant and discuss the merits of developing HSP72 as a therapeutic for rapid delivery to cells and tissues after a traumatic event. We also discuss the fusion of HSP72 to a cell-penetrating single-chain Fv (scFv) antibody fragment derived from mAb 3E10, referred to as Fv-HSP70. This fusion construct has been validated in vivo in a cerebral infarction model and is currently in testing as a clinical therapeutic to treat ischemic events and as a fieldable medical countermeasure to treat inhalation of toxicants caused by terrorist actions or industrial accidents.

KW - HSP70

KW - HSP72

KW - oxidative stress

KW - apoptosis inhibitor

KW - medical countermeasure

KW - reperfusion therapy

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940224/

U2 - 10.1111/nyas.13059

DO - 10.1111/nyas.13059

M3 - Article

C2 - 27152638

VL - 1374

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Targeted Heat Shock Protein 72 (HSP72) for Pulmonary Cytoprotection

Abstract

Keywords

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