This presentation focuses on developing a bio-psycho-social-spiritual toolbox for effectively managing stress, fear, and depression to support optimal teaching and functioning. Learning outcomes for the presentation include describing the neurobiology of burn out, exploring responses to stressful situations found in the Scriptures, practicing using tools introduced in the presentation to help regulate stress, fear, and depression, and applying content and skills taught in the presentation to develop a personal bio-psycho-social-spiritual toolbox for effectively managing stress, fear, and depression.